A vaudeville comic and a pretty young dancer aren’t having much luck in their separate careers, so they decide to combine their acts. In order to save money on the road, they get married. Soon their act begins to catch on, and they find themselves booked onto Broadway. They also realize that they actually are in love with each other, but just when things are starting to look up, the comic starts to let success go to his head.
Abandoning artistic ambitions, sensitive and club-footed Philip Carey enrolls in medical school and falls in love with a waitress Mildred Rogers. She rejects him, runs off with a salesman and returns unmarried and pregnant. Philip gets her an apartment and they become engaged. Mildred runs off with another medical student. Philip takes her back again when she returns with her baby. She wrecks his apartment and burns the securities he needs to pay tuition. He gets a job as a salesman, has surgery on his foot, receives an inheritance, and returns to school where he learns Mildred is dying.