A couple of teenagers are reported missing in a small Texas town, and it is thought they eloped. Sheriff Jeff turns to his friend Clarence Winstead, a garage mechanic and leader of a hot-rod gang, for help. After a series of tragic motor accidents, it becomes apparent that a giant Gila monster is roaming the area depleting the town of its citizens and visitors, including two hot-rodding teens, and planning to attend the BIG record-hop party.
A disparate group are trapped on a remote island by a hurricane. On the island, a doctor works to make humans twice as small as we already are. This, apparently, will help prevent over population. Unfortunately, his experiments have also created some giant shrews. As the shrews run out of smaller animals to eat, they move in on the people in the house.